Opioid prescriptions significantly higher for patients with lifelong disabilities

It's the largest study to examine opioid prescription patterns for adults living with cerebral palsy and spina bifida.

9:00 AM

Author | Noah Fromson

prescription pad lab notes
Jacob Dwyer, Justine Ross, Michigan Medicine

A Michigan Medicine study finds that people with two pediatric-onset neurodevelopmental disorders are prescribed opioids at significantly higher rates than those without the conditions, raising concerns over substance use disorders, overdose and mental health issues.

Researchers analyzed prescriptions of opioids from private insurance claims of over 22,000 patients with cerebral palsy or spina bifida, and more than 930,000 patients without the conditions.

They found that oral morphine equivalents, derived from medications such as oxycodone, codeine and morphine, were prescribed to patients with cerebral palsy and spina bifida at a rate up to five times higher than patients who do not have those conditions. The higher prescription patterns spanned across people with no pain, isolated and chronic pain, according to results published in Heliyon (a Cell Press journal).

"Our findings are of great concern, given the known links between persistent opioid use and psychiatric conditions, as well as with overdose mortality," said Mark Peterson, Ph.D., M.S., lead author of the paper and an associate professor of physical medicine and rehabilitation at University of Michigan Medical School.

SEE ALSO: Just over half of Michigan pharmacies offer overdose-fighting naloxone without prescription

Chronic pain is the most commonly reported symptom among patients with cerebral palsy, a neurological condition caused by abnormalities in the brain, and spina bifida, a neural tube defect that can damage the spinal cord and nerves. Pain in these individuals may arise from several issues, including muscle spasticity, arthritis and invasive surgical procedures.

Previous studies found that more than 40% of all Medicaid beneficiaries with a disability took opioid pain relievers, with more than 20% reporting chronic opioid use. The research team raises concerns over whether long-term opioid use is appropriate for the treatment of non-cancer-related chronic pain.

SEE ALSO: Use of opioids before surgery predicts consumption of opioids after surgery

Future studies must examine the effectiveness of non-opioid pain medications and alternative pain management strategies for adults living with cerebral palsy and spina bifida, says co-author Edward Hurvitz, M.D., chair of the U-M Health Department of Physical Medicine and Rehabilitation and a professor at U-M Medical School.

"Improving clinical pain screening strategies and developing efficient referral resources for appropriate pain management may help reduce the burden of opioid addiction and overdose in these populations by matching treatments to underlying pain mechanisms," Hurvitz said.

Additional authors include: Neil Kamdar, M.A., Jeidi J. Haapala, M.D., Chad Brummett, M.D., all of Michigan Mecdicine

This research was developed in part under a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR #90RTHF0001-01-00).

Paper cited: "Opioid prescription patterns among adults with cerebral palsy and spina bifida," Heliyon. DOI: 10.1016/j.heliyon.2022.e09918

Live your healthiest life: Get tips from top experts weekly. Subscribe to the Michigan Health blog newsletter

Headlines from the frontlines: The power of scientific discovery harnessed and delivered to your inbox every week. Subscribe to the Michigan Health Lab blog newsletter


More Articles About: Lab Notes Physical Medicine & Rehabilitation Addiction and Substance Abuse Medication Guidelines Pharmacy
Health Lab word mark overlaying blue cells
Health Lab

Explore a variety of healthcare news & stories by visiting the Health Lab home page for more articles.

Media Contact Public Relations

Department of Communication at Michigan Medicine

[email protected]

734-764-2220

Stay Informed

Want top health & research news weekly? Sign up for Health Lab’s newsletters today!

Subscribe
Featured News & Stories Illustration of a surgery table
Health Lab
Is surgery the best option for ruptured Achilles tendons in young adults?
Achilles tendon ruptures are normally treated with surgical procedures, but there are other options with equal outcomes.
Older man with hand on forehead, dressed in camouflage clothing
Health Lab
Ketamine helped many severely depressed veterans, study shows
Intravenous (IV) ketamine helped relieve the depression symptoms of half of the veterans who received it at VA hospitals.
Illustration of physician with prescriptions, indicating online options
Health Lab
Few older adults use direct-to-consumer health services; those who do don’t tell their regular provider
Buying health care services directly online offers convenience but also risks if patients don’t tell their regular doctor or provider. Poll looks at older adults’ use and attitudes.
AI algorithm alcohol medical symbols
Health Lab
For surgery patients, AI could help reduce alcohol-related risks
Surgery patients who drink at a risky level have higher risks of complications; surgical teams could use artificial intelligence to search their records for signs that they may need to cut back.
arm see through smiling faces blue yellow hammer and fit hitting arm
Health Lab
Persistent pain in your funny bone? It could be ulnar neuropathy
A Michigan Medicine expert breaks down what ulnar neuropathy is and how electrodiagnostic studies can assess severity and guide management, which can sometimes include conservative treatment and education on how to protect the nerve.
cbd oil bottles dropper bag container grene pink yellow pink blue purple
Health Lab
The growing use of hemp-derived alternative cannabis products containing CBD, Delta-8-THC, CBG, CBN
A Michigan Medicine study published in JAMA Network Open examines past-year use of some of these hemp-derived cannabinoids, including cannabidiol, Delta 8-THC, cannabigerol and cannabinol.