Doctors Unleash New Weapon to Fight Pediatric Neuroblastoma

More than half of children saw either partial or complete cancer remission in an international clinical trial — an "extraordinary success."

4:30 PM

Author | Beata Mostafavi

For seven months, three-year-old Emil Abbasov underwent chemotherapy to fight the tangerine-sized, cancerous tumor growing in his abdomen. But each time, the tumor resisted harder. Each time, he felt more treatment side effects.

Surgery helped remove some of the tumor, but not enough. So doctors at the University of Michigan's C.S. Mott Children's Hospital took a new approach, combining immunotherapy and chemotherapy in a nonconventional way.

After 17 rounds of the combination treatment, Emil's tumor was completely gone.

The now-first grader is among a group of patients with hard-to-treat neuroblastoma who responded so well to the novel treatment combination in a Children's Oncology Group international clinical trial that researchers plan to expand the study to include more children. C.S. Mott pediatric oncologist Rajen Mody, M.D., who led the research, recently presented the preliminary findings at the American Society of Clinical Oncology meeting.

When standard therapies don't work, as in Emil's case, or the cancer returns, the battle against the disease is grim — less than 5 percent of these young patients survive.

After the first year of receiving the novel treatment combination in the COG trial, 9 out of 17 children with relapsed neuroblastoma saw either a complete or partial remission — a 53 percent response rate compared to the typical 10 to 12 percent response rate from chemotherapy or biologic therapy alone.   

"The outcomes for relapsed neuroblastoma are dismal, and treatment options are limited," Mody says. "We found that in more than half of patients receiving this new combination therapy, the tumor either shrank or completely disappeared, which we consider an extraordinary success. Our study was small, but the results are so striking, they warrant further research to study the biological basis of why this combination of immunotherapy and chemotherapy works so well."

The phase II COG trial involved 35 patients, but researchers are planning to open a larger form of the trial soon.

Emil Abbasov, now 7, participated in a clinical trial to combat his hard-to-treat neuroblastoma.

How it works

Neuroblastoma is a solid tumor caused by uncontrolled or abnormal cell growth in nerve cells. Doctors think the cancer cells in patients whose bodies resist neuroblastoma treatment have found a way to keep immune cells from doing their job: fighting the cancer cells.

Typically, patients with neuroblastoma undergo one of two types of therapy — chemotherapy, which uses drugs to stop or slow the growth of cancer cells, or immunotherapy, which stimulates the immune system to work harder or smarter to attack cancer cells. The two treatments have typically been used on their own, however, not simultaneously.

The COG trial provided patients with a novel combination of chemotherapy and immunotherapy drugs to re-engage the immune cells to recognize and attack the cancer cells. The combination has been used successfully in other diseases, such as lymphoma.

Emil's mother, Feruza Alishanova, recalls watching her son "get weaker every day while the cancer got stronger," and says the disease seeming "unbeatable." She's thankful he responded to the new therapy and hopes more research helps other children, too. Emil, now seven years old, lives in Okemos, Michigan.

Neuroblastoma affects about 700 people a year in the U.S. and accounts for 6 percent of all childhood cancers in the country. The disease sometimes forms before birth, but is most often discovered later in life as the tumor grows and affects the body.

We hope this is the beginning of a path to learning how to cure cancer in more children facing this devastating disease.
Rajen Mody, MBBS

"What we are learning through this research could revolutionize treatment for children with relapsed or hard to treat neuroblastoma," Mody says. "We hope this is the beginning of a path to learning how to cure cancer in more children facing this devastating disease."

The new research comes on the heels of additional major findings in the area of precision oncology released by U-M in 2015 involving genome sequencing to help determine the best treatment options for children with rare, aggressive and advanced cancer.

Learn more about related research at www.mottchildren.org/cancer.


More Articles About: Lab Report Pediatric Cancer Cancer Research Children's Health
Health Lab word mark overlaying blue cells
Health Lab

Explore a variety of healthcare news & stories by visiting the Health Lab home page for more articles.

Media Contact Public Relations

Department of Communication at Michigan Medicine

[email protected]

734-764-2220

Stay Informed

Want top health & research news weekly? Sign up for Health Lab’s newsletters today!

Subscribe
Featured News & Stories cancer cell blue yellow
Health Lab
Targeted drug shows promising ability in treating rare head and neck cancers
Experts at Rogel Cancer Center develop and study the impact of a new drug for salivary gland cancers
Adult performs CPR on a young athlete, illustration with red and blue figures
Health Lab
Sudden cardiac arrest in young athletes: 5 things parents should know
Sudden cardiac arrest in young athletes: 5 things parents should know
Health care provider loads syringe with measles vaccine
Health Lab
Measles: 10 things to know about immunization and prevention
Measles: 10 things to know about immunization and prevention
Illustration of girl with blue water line, depicting a figure drowning, as girl contemplates pill in hand
Health Lab
Antidepressant dispensing to adolescents and young adults surges during pandemic
Rate of antidepressant dispensing to young people rose faster after March 2020, especially among females
Breaking Down Mental Health on blue background and text inside a yellow head graphic
Breaking Down Mental Health
Depression and Sleep
In this episode, learn to understand the interplay between depression and how cognitive behavioral therapy can improve sleep.
Mom and daughter pose in two separate photos about 30 years apart. Daughter had a congenital heart issue, now is an adult.
Health Lab
Mother daughter duo reflect on nearly three decade heart journey
Mother, daughter reflect on congenital heart treatment and decades long treatment