The study finds nearly 96% of patients deemed eligible for surgery survive in the first 48 hours.
The chance of a patient living after tearing their aorta has improved significantly, but the condition remains deadly if not recognized early and repaired surgically, a study finds.
A team of researchers examined early mortality rates for over 5,600 patients admitted to the hospital and examined hourly with type A acute aortic dissection between 1996 and 2018 from the International Registry for Acute Aortic Dissection. The often-fatal dissection occurs when blood rushes through a tear in the ascending aorta, causing its layers to separate.
Findings published in JAMA Cardiology reveal that 5.8% of patients with type A acute aortic dissection died within the first two days after hospital arrival, a mortality rate of 0.12% per hour. The rate is significantly lower than that reported in the 1950s, which estimated that 37% of patients died within the first 48 hours, with an increasing mortality rate of 1-2% per hour.
"We believe that advances in diagnosis and management, especially a focus on early surgical repair, may have contributed in part to these improvements in mortality for acute aortic dissection," said Kim Eagle, M.D., MACC, senior author of the paper and director of the University of Michigan Health Frankel Cardiovascular Center.
Of all the patients, 91% either received surgery or were intended for surgery, with the others managed medically due to advanced age and complications, such as stroke and kidney failure. Nearly 24% of those receiving medical treatment alone died within two days, compared to 4.4% of patients treated with surgical repair – a death rate more than 5 times higher.
"Patients who were managed medically were likely not surgical candidates due to their comorbidities," said Bo Yang, M.D., a professor of cardiothoracic surgery at University of Michigan Medical School who was not involved in the study. "The medically managed patients could die from aortic dissection-associated complications – such as malperfusion, cardiac tamponade, aortic rupture and acute aortic insufficiency, which can be treated with surgery – or from their existing medical conditions which could be worsened by the aortic dissection."
Only 1% of patients deemed OK for surgery died before the procedure. These patients died after an average of nearly nine hours from being admitted to the hospital, exceeding the six-hour median time to surgery for all patients.
Interhospital transfer is needed in more than 70% of aortic dissection cases, causing inherent delays. Before this study, Eagle says, it was thought that early death from this condition was so prohibitive that operating urgently, even in hospitals with limited volume of aortic dissection surgery and resources, was the preferred strategy.
It is clear that the 'cost', or risk, of a four-to-six-hour delay caused by transfers is more than offset by the lower risk of surgery at experienced hospitals.Kim A. Eagle, M.D., M.A.C.C. Photo
However, there is evidence that surgery at a low-volume hospital can double the risk of dying while undergoing repair compared to the highest volume providers. Additionally, mortality rates for open repair of acute type A aortic dissection are nearly three times higher when the operation is not performed by a dedicated aortic surgeon.
"Hospital mortality at a high-volume center like U-M, where aortic dissection patients are taken care only by highly experienced aortic surgeons, can be as low as 5%, while the same patient operated on at a low-volume center may be 20% or higher," Eagle said. "With this new information, it is clear that the 'cost', or risk, of a four-to-six-hour delay caused by transfers is more than offset by the lower risk of surgery at experienced hospitals."
Cases are rare. Approximately three in 100,000 people suffer aortic dissection each year. The condition most commonly affects older men, and a person experiencing the tear may feel a "knifelike, tearing pain through the back," according to IRAD.
It's estimated that up to 50% of patients will die before ever reaching the hospital, making the overall mortality for aortic dissection substantially higher.
"There is a need to identify the high-risk population of aortic dissection, such as those with a family history of aortic aneurysm and dissection, especially at a younger age, or known pathogenic genetic variants, so that we can replace the proximal aorta electively to prevent acute type A aortic dissection," Yang said. "For young people under 55 years old with severe chest pain, we have to prove if patients have aortic dissection or otherwise."
The International Registry of Aortic Dissection was founded at the University of Michigan in 1996. There are currently 58 aortic centers around the world participating in this ongoing collaborative.
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Additional Authors include Elise M. Woznicki, B.S., Daniel G. Montgomery, B.S., both of Michigan Medicine, Kevin M. Harris, M.D., Craig Strauss, M.D., both of the Minneapolis Heart Institute Foundation, Christoph A. Nienaber, M.D., The Royal Brompton & Harefield NHS Foundation Trust, Mark D. Peterson, M.D., University of Toronto, Alan C. Braverman, M.D., Washington University School of Medicine, Santi Trimarchi, M.D., Ph.D., Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Truls Myrmel, M.D, Ph.D., Tromsø University Hospital, Reed Pyeritz, M.D., Perelman School of Medicine, Stuart Hutchison, M.D., University of Calgary, Marek P. Ehrlich, M.D., Medical University of Vienna, Thomas G. Gleason, M.S., M.D., Brigham and Women's Hospital, Amit Korach, M.D., Hadassah Hebrew University Medical Center, Eric M. Isselbacher, M.D., Massachusetts General Hospital
Dr Eagle reported grants from W.L. Gore & Associates, Medtronic, and Terumo during the conduct of the study.
Paper cited: "Early Mortality in Type A Acute Aortic Dissection: Insights From the International Registry of Acute Aortic Dissection," JAMA Cardiology. DOI: 10.1001/jamacardio.2022.2718
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