Nearly a Quarter of Antibiotic Prescriptions May Be Unnecessary

1 in 7 privately insured children and non-elderly adults among study cohort received antibiotics for cases that were not medically justified, new research finds.

5:06 PM

Author | Beata Mostafavi

One in 10 children and about one in six adults with private insurance received antibiotics they didn't need at least once in 2016, a new Michigan Medicine study suggests.

Overall, 1 in 7 patients received unnecessary antibiotics, researchers found.  Of outpatient antibiotic prescriptions filled by 19.2 million privately insured U.S. children and adults ages 18-64 in 2016, 23 percent were not medically justified, 36 percent were potentially appropriate, and 28 percent were not associated with any documented diagnosis.

The research, published in the British Medical Journal, provides the most recent and comprehensive estimates of outpatient antibiotic appropriateness to date among privately insured patients.

"Antibiotic overuse is still rampant and affects an enormous number of patients," says lead author Kao-Ping Chua, M.D., Ph.D., a researcher and pediatrician at University of Michigan C.S. Mott Children's Hospital and the U-M Institute for Healthcare Policy and Innovation.

LISTEN UP: Add the new Michigan Medicine News Break to your Alexa-enabled device, or subscribe to our daily audio updates on iTunes, Google Play and Stitcher.

"Despite decades of quality improvement and educational initiatives, providers are still writing antibiotic prescriptions for illnesses that would get better on their own."

Roughly 2.2 million (15 percent) of the 14.6 million adult enrollees filled at least one inappropriate antibiotic prescription in 2016, compared to 490,745 (11 percent) of those filled for the 4.6 million children. Antibiotics were most commonly overprescribed for bronchitis, the common cold, and related symptoms such as cough – conditions that the medicine does not improve.

Among the 3.6 million inappropriate antibiotic prescription fills, 71 percent were written in office-based settings, 6 percent in urgent care centers, and 5 percent in emergency departments. 

The harms of overuse

In children, antibiotics are the leading cause of emergency room visits for adverse drug events, according to a recent Centers for Disease Control and Prevention study. Potential side effects include allergic reactions, fungal infections and diarrhea.

Long term, Chua says, the biggest concern is that antibiotic overuse is contributing to the development of antibiotic-resistant bacteria, causing illnesses that were once easily treatable with antibiotics to become untreatable and dangerous. Each year in the U.S., 2 million people are affected by antibiotic-resistant infections and 23,000 die, according to the Centers for Disease Control and Prevention.

The study found that the rate of antibiotic prescriptions is 805 per 1,000 people. National data indicate that around 270 million antibiotic prescriptions are filled every year.

"Antibiotic resistance is one of the greatest threats to public health in the world, and the large number of antibiotics that providers prescribe to patients is a major driver of resistance," Chua says.

"Providers urgently need to eliminate prescribing that isn't needed, both for the sake of their patients and society."

Despite decades of quality improvement and educational initiatives, providers are still writing antibiotic prescriptions for illnesses that would get better on their own.
Kao-Ping Chua, M.D., Ph.D.

Chua notes several possible explanations for inappropriate prescriptions. In some cases, patients may ask for a prescription to reduce suffering, particularly if they have been inappropriately prescribed antibiotics in the past in similar situations, leading them to believe antibiotics are necessary.

In other cases, doctors may truly be unsure about the diagnosis.

"Providers are well meaning and want to care for their patients the best way they can," Chua says. "It's sometimes difficult to differentiate between a cold and a bacterial sinus infection. Diagnostic uncertainty is definitely one factor.

"However, even when providers think a patient likely has a cold, our medical culture encourages them to risk over treating rather than risk undertreating by recommending watchful waiting."

Chua also notes that the percentage of prescriptions that are unnecessary may be much higher than what the numbers show. Three in 10 fills were not associated with any documented diagnosis. These could include cases where a doctor prescribed an antibiotic over the phone without an office visit based on descriptions matching an infection requiring antibiotics.

MORE FROM MICHIGAN: Sign up for our weekly newsletter

The 36 percent of fills considered potentially appropriate in the study were also written for conditions that only sometimes need antibiotics, like sinusitis.

How they did it 

Chua and colleagues analyzed insurance claims data using a novel classification system determining whether each of the 91,738 diagnosis codes available in the international medical coding system "always," "sometimes," or "never" justified antibiotics.  No study has examined outpatient antibiotic appropriateness using a comprehensive classification scheme of diagnosis codes contained in the newest medical coding system (ICD-10, which replaced ICD-9 in the U.S. in 2015.) Prior studies have used pre-2015 data because of their reliance on ICD-9.

Chua says the classification scheme could help providers better evaluate how often they are overprescribing antibiotics and could also help evaluate the effectiveness of interventions to reduce antibiotic overuse.

"Our classification scheme could facilitate future efforts to comprehensively measure outpatient antibiotic appropriateness in the U.S. It could also be used in other countries that are already using ICD-10," he says.


More Articles About: Rounds Health Care Delivery, Policy and Economics Medication Guidelines Pediatric Health Conditions
Health Lab word mark overlaying blue cells
Health Lab

Explore a variety of health care news & stories by visiting the Health Lab home page for more articles.

Media Contact Public Relations

Department of Communication at Michigan Medicine

[email protected]

734-764-2220

Stay Informed

Want top health & research news weekly? Sign up for Health Lab’s newsletters today!

Subscribe
Featured News & Stories girl in room looking back grey
Health Lab
Study: Half of pediatric opioid prescriptions are “high risk”
The top 5% of prescribers account for half of opioid prescriptions and high risk prescriptions to children and young adults.
yellow background with hand in orange with invisible pills falling out of pill bottle
Health Lab
Antibiotic prescriptions for kids plummet during pandemic
Study finds declines in prescription drugs dispensed to children during COVID-19, including infection-related medicines and some used for chronic diseases.
Opioid adolescents image
Health Lab
Opioid Overdose Risk Factors for Teens, College-Aged Youth Mirror Adults
Study finds teens and college-aged youth are at equal risk as their adult counterparts for opioid overdoses.
Little girl in bed with a woman next to her with a bottle of medicine in her hand
Health Lab
6 in 10 Kids Receive Opioids After Tonsillectomy, But Opioids May Not Prevent Complications
Approximately 60% of children receive an opioid prescription for post-operative pain following tonsillectomies, but a new study finds that opioids may not prevent complications.
two women, one older one younger, looking concerned listening to a provider across from them with back to camera
Health Lab
Many breast cancer survivors don't receive genetic testing, despite being eligible
As cancer treatment and survivorship care relies more on understanding the genetic make up of an individual’s tumor, a study from the University of Michigan Health Rogel Cancer Center finds that many breast cancer survivors who meet criteria for genetic counseling and testing are not receiving it.
Health Lab Podcast in brackets with a background with a dark blue translucent layers over cells
Health Lab Podcast
Addressing health care inequality
An expert on racial and ethnic differences in health care and health outcomes offers recommendations as part of a national committee.