Nearly 60% of Pinkeye Patients Receive Antibiotic Eye Drops, But They're Seldom Necessary

Ophthalmologists urge providers to stop prescribing antibiotics for a common eye condition that typically clears up without medication.

7:00 AM

Author | Shantell M. Kirkendoll

A new study suggests that most people with acute conjunctivitis, or pinkeye, are getting the wrong treatment.

MORE FROM THE LAB: Subscribe to our weekly newsletter

About 60 percent of patients nationwide are prescribed antibiotic eye drops, even though antibiotics are rarely necessary to treat this common eye infection. Of the patients filling antibiotic prescriptions, 20 percent filled prescriptions for antibiotic-steroid eye drops that can prolong or worsen the infection.

The study by the University of Michigan Kellogg Eye Center is consistent with a nationwide trend of antibiotic misuse for common viral and mild bacterial conditions. It's a trend that increases costs to patients and the health care system and may promote antibiotic resistance.

"This study opens the lid on overprescribing of antibiotics for a common eye infection," says lead study author Nakul Shekhawat, M.D., M.P.H., resident physician at Kellogg.

Using data from a large managed care network in the United States, researchers identified the number of patients who filled antibiotic eye drop prescriptions for acute conjunctivitis. They then evaluated the characteristics of patients who filled prescriptions compared to those who did not.

Among 340,372 people diagnosed with acute conjunctivitis over a 14-year period, 58 percent filled a prescription for antibiotic eye drops.

Most patients were diagnosed by nonspecialists, such as a family medicine physician, pediatrician, internal medicine physician or urgent care provider. Only a minority were diagnosed by eye care specialists such as ophthalmologists or optometrists.

Patients diagnosed by a primary care or urgent care provider were two to three times more likely to fill prescriptions for antibiotic eye drops than patients diagnosed by an ophthalmologist.

Even more troubling, the Kellogg Eye Center study found the odds of filling a prescription depended more on a patient's socioeconomic status than the patient's risk for developing a more serious eye infection. For example, contact lens wearers or those with diabetes or HIV/AIDS are more at risk.

The study shows that current treatment decisions for pinkeye are not based on evidence but are often driven more by type of health care practitioner making the diagnosis and the patient's socioeconomic status than by medical reasons.
Nakul Shekhawat, M.D., M.P.H.

Patients who filled antibiotic prescriptions were significantly more likely to be white, younger, better educated and more affluent than patients who did not fill prescriptions.

This is the first study to focus on outpatient management of acute conjunctivitis in the United States. It was published in Ophthalmology, the journal of the American Academy of Ophthalmology.

"The study shows that current treatment decisions for pinkeye are not based on evidence but are often driven more by type of health care practitioner making the diagnosis and the patient's socioeconomic status than by medical reasons," Shekhawat says. "The potential negative consequences are difficult to justify as we move toward focusing on value in health care."

Pinkeye affects 6 million people in the United States each year and is a major driver of emergency room visits for ocular problems. There are three types: viral, bacterial and allergic conjunctivitis. Most cases are caused by viral infections or allergies and do not respond to antibiotics. Artificial tears and warm compresses may help keep the eye comfortable while viral conjunctivitis runs its course.

SEE ALSO: 1 in 4 ER Visits for Eye Problems Aren't Actually Emergencies

Antibiotics are often unnecessary for bacterial conjunctivitis because most cases are mild and would resolve on their own within seven to 14 days without treatment.

Authors say there are several reasons why antibiotics are overprescribed:

Cause unknown. It is a challenge to differentiate bacterial conjunctivitis from the viral and allergic forms. All three types may have overlapping features, such as a red eye, thin discharge, irritation and sensitivity to light. Health care providers may be unsure of the cause and prescribe antibiotics "just in case." Several rapid, point-of-care tests for adenovirus are in development that could save an estimated $400 million in health care spending in the U.S. alone.

School policies. Children with pinkeye may not be able to attend school or day care unless they are being treated, presumably to reduce transmission. In an accompanying editorial, such policies were called "highly inconvenient for patients and parents" and "devoid of evidence," considering the more rapidly spreading viral conjunctivitis is unlikely to be influenced by a topical antibiotic.

Lack of education. Patients are often unaware of the harmful side effects of antibiotics and may falsely believe that antibiotics are necessary for the infection to resolve.

Senior study author and Kellogg ophthalmologist Joshua Stein, M.D., director of the Center for Eye Policy and Innovation, says a new approach is needed for managing acute conjunctivitis that involves patients, health care providers and policymakers.

"Educating patients about acute conjunctivitis' often benign, self-limited course may help to dispel misconceptions about the condition and reduce reflexive demands for immediate antibiotic use," says Stein, who is also a member of the U-M Institute for Healthcare Policy and Innovation.

The American Academy of Ophthalmology has issued guidance to the medical community on treatment for pinkeye. The Academy tells health care providers to avoid prescribing antibiotics for viral conditions and to delay immediate treatment when the cause of conjunctivitis is unknown.


More Articles About: Rounds Kellogg Eye Center Eye Care & Vision Children's Health Hospitals & Centers
Health Lab word mark overlaying blue cells
Health Lab

Explore a variety of healthcare news & stories by visiting the Health Lab home page for more articles.

Media Contact Public Relations

Department of Communication at Michigan Medicine

[email protected]

734-764-2220

Stay Informed

Want top health & research news weekly? Sign up for Health Lab’s newsletters today!

Subscribe
Featured News & Stories Minding Memory with a microphone and a shadow of a microphone on a blue background
Minding Memory
Vision Impairment as a Risk Factor for Dementia
The population of older adults living with dementia is expected to swell to nearly 14 million by 2050 and is estimated to cost the US economy more than 500 billion each year. In the absence of a cure for Alzheimer's disease, the primary cause of dementia, there's interest in understanding modifiable risk factors. In theory, getting a handle on the modifiable risk factors for dementia, would enable public health efforts to reduce cognitive decline in dementia at the population level. We've come a long way in understanding the risk factors for Alzheimer's disease and other related dementias. However, there's still work to be done. In this episode, we'll speak with Dr. Josh Ehrlich, a researcher at the University of Michigan, who has examined vision impairment as a risk factor for dementia.
sketched out bacteria in a dish yellow and blue colors of U-M
Health Lab
This gross mixture has big benefits for the study of bacteria
Michigan Medicine researchers have found that growing bacteria on agar mixed with organs is an efficient and effective way to study infectious pathogens.
three pharmacists smiling
Health Lab
An innovative pharmacy service for pain management
An innovative service at Michigan Medicine offers pain management support for patients and care teams
family smiling togehter
Health Lab
Ketogenic diet helps 4-year-old live seizure free
Last year, a young girl experienced up to 40 seizures a week. Today, after nearly a year of working with the ketogenic diet team at University of Michigan Health C.S. Mott Children’s Hospital – overseen by a pediatric neurologist and dietitian – she’s celebrating six months of seizure freedom.
woman listening to different shadow windows of people saying different things about kids
Health Lab
Parents of young kids increasingly turn to social media for parenting advice
A C.S. Mott Children's Hospital health poll found most mothers and over two-thirds of fathers of children ages 0-4 use social media for questions on topics like feeding and behavior challenges.
human organ for transplant
Health Lab
Findings shed light on how a pediatric heart surgery complication impacts heart transplant survival
Patients who experience this condition following the Fontan continue to have a high risk of death from the time they’re waitlisted for a new heart through receiving the transplant, according to a 20-center study led by Michigan Medicine. And one specific complication called cyanosis – or experiencing less than normal oxygen blood levels – was associated with worsened survival.