Protecting newborns from hepatitis B

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Medical experts are urging continued hepatitis B vaccine birth doses for newborns. This recommendation is based on decades of data showing that policies put in place for hepatitis B vaccines that have long been the status quo are estimated to have prevented one million hospitalizations and 90,000 deaths. Read the full article.

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Welcome to Health Lab, your destination for news and stories about the future of healthcare. 

Today, we’re talking about protecting newborns from hepatitis B. Medical experts are urging continued hepatitis B vaccine birth doses for newborns. This recommendation is based on decades of evidence showing that policies put in place for hepatitis B vaccines that have long been the status quo are estimated to have prevented one million hospitalizations and 90,000 deaths.

In a commentary published in Gastroenterology, leading experts are urging that all newborns in the United States continue to receive the first dose of the hepatitis B vaccine within 24 hours of birth. 

Hepatitis B vaccines are safe and effective with over one billion doses having been administered worldwide. 

Since 1991, the Centers for Disease Control and Prevention (CDC) and the Advisory Committee on Immunization Practices have recommended the hepatitis B vaccine for all infants, not just those born to mothers who have tested positive for hepatitis B, with the first dose given within 24 hours of birth for infants born to mothers who tested positive for hepatitis B. 

Their recommendation was updated in 2005 to specify that the first dose should be administered within 12 hours of birth for infants born to mothers who tested positive for hepatitis B and before hospital discharge for other infants. 

In 2018, the timing of the first dose was updated to be within 24 hours of birth for all infants, including pre-term infants and those born to mothers who tested negative for hepatitis B. 

The authors of this commentary have identified this universal “birth dose” as an essential safety net for preventing chronic hepatitis B infection, which can lead to premature death from cirrhosis or liver cancer. 

The result of these policies has been a 95% decline in infant hepatitis B infections, which have prevented an estimated one million hospitalizations and 90,000 deaths. 

In the following Q&A, first author Anna S. Lok, M.D., the Alice Lohrman Andrews Research Professor of Hepatology at Michigan Medicine, discusses the importance of continued universal hepatitis B vaccination for children at birth. 

Let’s jump in.

Question number 1: Why is it important that all children receive a hepatitis B vaccine at birth, not just children born to mothers who have tested positive? 

Dr. Lok says, “We don’t know the status of every mother—the U.S. healthcare system is not perfect. A lot of people don't have insurance, or they show up very late to the hospital. They show up when they're in labor, and you may not necessarily have the ability to check the mother's status. But if you vaccinate every newborn baby, then you don't need to worry about infants whose mother has unknown hepatitis B status.” 

Dr. Lok goes on, “The other issue is that we assume that the only source of infection is from the mother, but that's not true, because some babies can be infected through other people. There is evidence that fathers can transmit the infection. In some families, it could be the grandparents taking care of the baby. Or it could be the nanny who's taking care of the baby. Or you drop off your baby at daycare. And you don't know the status of people in daycare, or the other kids in daycare. Now, of course, the contact between the other people and the baby is different from the contact between the mother and the baby. But babies do get scratches, and the skin may break. If babies are to get infected, they have a 90% chance of going on to chronic infection, which can lead to cirrhosis and liver cancer and early death. If your immune system is mature and you get infected when you're an adult, then your chance of getting chronic infection is only 5%.” 

Question number 2: Why is it important that people are vaccinated for hepatitis B as children? 

Dr. Lok says, “In addition to the 90% chance of chronic infection, if children are infected, they can further spread the infection. She goes on, “The other issue is practicality. Trying to get adolescents and adults vaccinated is a very tricky issue, because we don't have a good infrastructure. Getting babies vaccinated on day 1 when they’re in the hospital has a much higher chance of getting it done.” 

Question 3: Are hepatitis B vaccines safe for children? 

Dr. Lok says, “The hepatitis B vaccine was first approved in 1981. More than 1 billion doses have already been administered. It's one of the few vaccines that were approved for use in newborns and for pregnant women. These are the most vulnerable people.”

Dr. Lok continues, “There are very few things that we approve for use in newborn babies within the first 12-24 hours of birth. There are very few things that we feel comfortable in recommending for use during pregnancy.” 

Question 4: What is your overall message to parents and policymakers on this issue? 

Dr. Lok says, “We have safe and effective vaccines that have been around for 45 years. And if we use the vaccine appropriately and give it to every single newborn baby at the time of birth, we can prevent infections. We don't need to worry about children getting chronic infections, cirrhosis and liver cancer. It's the most cost-effective way of preventing infection, rather than waiting for people to get infected and monitoring and treating them for the rest of their lives. We have treatment for hepatitis B but they do not eliminate the virus and do not cure the disease. 

Dr. Lok goes on, “If vaccines could prevent other chronic diseases, such as diabetes, I'm sure that we would. It's just that we don't have a vaccine for diabetes. We can prevent chronic hepatitis B, and we have a lot of data to show that vaccines work and are safe.”

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