Robert T Kennedy
Hobart H Willard Distinguished University Professor of Chemistry
Professor of Chemistry
College of Literature, Science, and the Arts
Professor of Pharmacology
Medical School
[email protected]

Available to mentor
Robert T Kennedy
Professor
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  • Qualifications
  • Center Memberships
  • Research Overview
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    About

    Robert Kennedy is a Professor of Chemistry and Pharmacology. His research interests are in bioanalytical chemistry with an emphasis on microfluidics, mass spectrometry, chromatography, and electrophoresis. He develops these methods to study neurotransmitter dynamics in vivo, hormone secretion, and for high-throughput experimentation.

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    • My Background
    Qualifications
    • PhD
      University of North Carolina-Chapel Hill, 1988
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    We develop and apply bioanalytical methods for studying hormone and neurtransmitter secretion. We develop microfluidic chips to culture cells and integrate methods to measure releasate. We also coupling sampling probes to analytical methods for in vivo brain chemical measurements. We develop metabolomics methods for studying biological systems. We have focused LC-MS/MS, capillary electrophoresis, and sensors for analysis. We have applied to study of islets of Langerhans and various rodent models in the brain.

    Recent Publications See All Publications
    • Preprint
      Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats.
      Glynos NG, Huels ER, Nelson A, Kim Y, Kennedy RT, Mashour GA, Pal D. 2025 Feb 15; DOI:10.1101/2024.04.19.589047
      PMID: 38712161
    • Journal Article
      Lipid Curvature and Fluidity Influence Lipid Incorporation Disparities in Nanodiscs
      Sarcinella MC, Jones JD, Sorensen MJ, Edgcombe SA, Ruotolo BT, Kennedy RT, Bailey RC. Analytical Chemistry, 2025 Feb 11; 97 (5): 2883 - 2889. DOI:10.1021/acs.analchem.4c05494
    • Journal Article
      In-Depth Chemical Analysis of the Brain Extracellular Space Using In Vivo Microdialysis with Liquid Chromatography-Tandem Mass Spectrometry
      Anderson BG, Popov P, Cicali AR, Nwamba A, Evans CR, Kennedy RT. Analytical Chemistry, 2024 Oct 15; 96 (41): 16387 - 16396. DOI:10.1021/acs.analchem.4c03806
    • Journal Article
      Conserved 5-methyluridine tRNA modification modulates ribosome translocation
      Jones JD, Franco MK, Giles RN, Eyler DE, Tardu M, Smith TJ, Snyder LR, Polikanov YS, Kennedy RT, Niederer RO, Koutmou KS. Proceedings of the National Academy of Sciences of the United States of America, 2024 Aug 27; 121 (35): DOI:10.1073/pnas.2401743121
      PMID: 39159370
    • Journal Article
      Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis.
      Jun H, Liu S, Knights AJ, Zhu K, Ma Y, Gong J, Lenhart AE, Peng X, Huang Y, Ginder JP, Downie CH, Ramos ET, Kullander K, Kennedy RT, Xu XZS, Wu J. PLoS Biology, 2023 Jun 2; 22 (7): e3002728 - e3002728. DOI:10.1371/journal.pbio.3002728
    • Journal Article
      Offline Two-Dimensional Liquid Chromatography-Mass Spectrometry for Deep Annotation of the Fecal Metabolome Following Fecal Microbiota Transplantation
      Anderson BG, Raskind A, Hissong R, Dougherty MK, McGill SK, Gulati AS, Theriot CM, Kennedy RT, Evans CR. Journal of Proteome Research, 2024 Jun 7; 23 (6): 2000 - 2012. DOI:10.1021/acs.jproteome.4c00022
      PMID: 38752739
    • Journal Article
      Preparation of high-efficiency HILIC capillary columns utilizing slurry packing at 2100 bar
      Anderson BG, Hancock TA, Kennedy RT. Journal of Chromatography A, 2024 May 10; 1722: DOI:10.1016/j.chroma.2024.464856
      PMID: 38579610
    • Journal Article
      Systematic evaluation of benzoylation for liquid chromatography-mass spectrometry analysis of different analyte classes
      Lenhart AE, Booth PPM, Simcox KM, Ramos BA, Kennedy RT. Journal of Chromatography A, 2024 May 10; 1722: DOI:10.1016/j.chroma.2024.464872
      PMID: 38581975