Roman Giger, PhD
Dr Richard Mark Newman Research Professor of Cell and Developmental Biology
Professor of Cell and Developmental Biology
Professor of Neurology
Medical School
[email protected]

Available to mentor

Roman Giger, PhD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
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    Qualifications
    • Postdoctoral fellow
      Johns Hopkins University School of Medicine, Neuroscience, 2001
    • postdoctoral fellow
      Netherlands Institute for Neuroscience, Amsterdam, 1997
    • PhD
      University of Zurich, 1995
    • MS
      University of Zurich, 1991
    • BS
      University of Zurich, 1990
    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Biosciences Initiative
    Research Overview

    Nervous system regeneration, sciatic nerve, optic nerve, axon growth, neuroinflammation, axon-glia interaction, myelination, mouse genetics

    Links
    • Giger Lab
    Recent Publications See All Publications
    • Preprint
      Assigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders
      Ellegood J, Beauchamp A, Yee YC, Devenyi GA, Ziolkowski J, Qiu LR, Askalan R, Ayub M, Suetterlin P, Donovan APA, Pérez-Sisqués L, Basson A, Quesnel K, Berube N, Woo T, Beversdorf D, Bjornsson H, Blakely R, Crawley J, Crosbie J, Orr BO, Davis G, Genestine M, DiCicco-Bloom E, Egan S, Fink KD, Asbury S, Lai J, Rilett K, Foster J, Vincent JB, Frankland PW, Georgiades S, Penagarikano O, Geschwind D, Giger RJ, Markx S, Gogos J, Golzio C, Pagani M, Gozzi A, Pacey LK, Hampson D, Huang T-N, Yen T-L, Hsueh Y-P, Iaboni A, Amar M, Iaokoucheva L, Jones JK, Kelley EA, Kieffer B, Bae M, Jung H, Kim H, Park H, Roh JD, Kim E, Konopka G, Laliberté C, Lefebvre J, Eagleson K, Levitt P, Martins-Bach AB, Cunningham TJ, Fisher E, Miller KL, Mills AA, Muotri AR, Nicolson R, Noakes LS, Nieman BJ, Canales C, Nord AS, Nutter LMJ, Tam E, Osborne LR, Clipperton-Allen A, Page D, Babineau B, Moon A, Palmer T, Yan K, Picketts DJ, Xia Q, Powell CM, Raznahan A, Robins DM, Rumbaugh G, Sengar AS, Salter MW, Schachar R, D’Abate L, Bradley CA, Scherer SW, Copping NA, Pektova SP, Silverman J, Singh K, Kim N-S, Yoon K-J, Ming G-L, Song H, Spring S, Nakatani J, Nakai N, Nomura J, Takumi T, Tsai P, Bruce M, Jones K, Van de Water J, van Eede MC, Kerr TM, Muller C, VanderWeele JV, Vandewouw M, Weksberg R, Wevrick R, Belinson H, Wynshaw-Boris A, Zarbalis K, Trost B, Taylor M, Mars RB, Chakravarty MM, Kushki A, Anagnostou E, Lerch JP. 2025 Mar 12; bioRxiv, DOI:10.1101/2025.03.04.641443
    • Journal Article
      Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature.
      Childs CJ, Poling HM, Chen K, Tsai Y-H, Wu A, Vallie A, Eiken MK, Huang S, Sweet CW, Schreiner R, Xiao Z, Spencer RC, Paris SA, Conchola AS, Villanueva JW, Anderman MF, Holloway EM, Singh A, Giger RJ, Mahe MM, Loebel C, Helmrath MA, Walton KD, Rafii S, Spence JR. Cell Stem Cell, 2025 Mar 21; S1934 - 5909. DOI:10.1016/j.stem.2025.02.007
    • Preprint
      Diverse and Location-Specific Roles of PlexinA2, PlexinA4, and NCAM in Developing Hippocampal Mossy Fibers
      Zhao X-F, Kohen R, Van Battum EY, Zeng Y, Zhang X, Johnson CN, Wang K, Lim BC, Oses-Prieto JA, Rasband JM, Burlingame AL, Pasterkamp RJ, Rasband MN, Giger RJ. 2024 Dec 19; bioRxiv, DOI:10.1101/2024.12.15.628586
    • Journal Article
      Structure and function of Semaphorin-5A glycosaminoglycan interactions
      Nagy GN, Zhao XF, Karlsson R, Wang K, Duman R, Harlos K, El Omari K, Wagner A, Clausen H, Miller RL, Giger RJ, Jones EY. Nature Communications, 2024 Dec 1; 15 (1): DOI:10.1038/s41467-024-46725-7
      PMID: 38548715
    • Preprint
      Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation.
      Hoard TM, Liu K, Cadigan KM, Giger RJ, Allen BL. 2024 May 29; DOI:10.1101/2024.05.29.596372
      PMID: 38854152
    • Preprint
      Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.
      Schmitd LB, Hafner H, Ward A, Asghari Adib E, Biscola NP, Kohen R, Patel M, Williamson RE, Desai E, Bennett J, Saxman G, Athaiya M, Wilborn D, Shumpert J, Zhao X-F, Kawaguchi R, Geschwind DH, Hoke A, Shrager P, Collins CA, Havton LA, Kalinski AL, Giger RJ. 2024 Apr 17; DOI:10.1101/2024.03.04.583374
      PMID: 38496662
    • Journal Article
      Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration
      Passino R, Finneran MC, Hafner H, Feng Q, Huffman LD, Zhao XF, Johnson CN, Kawaguchi R, Oses-Prieto JA, Burlingame AL, Geschwind DH, Benowitz LI, Giger RJ. Cell Reports, 2024 Mar 26; 43 (3): DOI:10.1016/j.celrep.2024.113931
      PMID: 38492223
    • Journal Article
      Abstract 1390 Repair Schwann Cell Reprogramming After Peripheral Nerve Injury
      Vitale S, Giger R, Schmitd LB, Haffner H. Journal of Biological Chemistry, 2024 Mar 27; 300 (3): 106740 DOI:10.1016/j.jbc.2024.106740
    Featured News & Stories
    Department News
    Congratulations to Roman Giger being named a AAAS Fellow!
    Roman Giger, Ph.D., is named as a 2024 American Association for the Advancement of Science (AAAS).
    Department News
    April 25, 2024 New Publication from the Giger Lab!
    "Structure and function of Semaphorin-5A glycosaminoglycan interactions," has been published in Nature Communications.