
Dr Richard Mark Newman Research Professor of Cell and Developmental Biology
Professor of Cell and Developmental Biology
Professor of Neurology
Medical School
[email protected]
Available to mentor
Roman Giger, PhD

Professor
-
Postdoctoral fellowJohns Hopkins University School of Medicine, Neuroscience, 2001
-
postdoctoral fellowNetherlands Institute for Neuroscience, Amsterdam, 1997
-
PhDUniversity of Zurich, 1995
-
MSUniversity of Zurich, 1991
-
BSUniversity of Zurich, 1990
-
Center MemberCenter for Cell Plasticity and Organ Design
-
Center MemberBiosciences Initiative
Nervous system regeneration, sciatic nerve, optic nerve, axon growth, neuroinflammation, axon-glia interaction, myelination, mouse genetics
Giger Lab
-
Ellegood J, Beauchamp A, Yee YC, Devenyi GA, Ziolkowski J, Qiu LR, Askalan R, Ayub M, Suetterlin P, Donovan APA, Pérez-Sisqués L, Basson A, Quesnel K, Berube N, Woo T, Beversdorf D, Bjornsson H, Blakely R, Crawley J, Crosbie J, Orr BO, Davis G, Genestine M, DiCicco-Bloom E, Egan S, Fink KD, Asbury S, Lai J, Rilett K, Foster J, Vincent JB, Frankland PW, Georgiades S, Penagarikano O, Geschwind D, Giger RJ, Markx S, Gogos J, Golzio C, Pagani M, Gozzi A, Pacey LK, Hampson D, Huang T-N, Yen T-L, Hsueh Y-P, Iaboni A, Amar M, Iaokoucheva L, Jones JK, Kelley EA, Kieffer B, Bae M, Jung H, Kim H, Park H, Roh JD, Kim E, Konopka G, Laliberté C, Lefebvre J, Eagleson K, Levitt P, Martins-Bach AB, Cunningham TJ, Fisher E, Miller KL, Mills AA, Muotri AR, Nicolson R, Noakes LS, Nieman BJ, Canales C, Nord AS, Nutter LMJ, Tam E, Osborne LR, Clipperton-Allen A, Page D, Babineau B, Moon A, Palmer T, Yan K, Picketts DJ, Xia Q, Powell CM, Raznahan A, Robins DM, Rumbaugh G, Sengar AS, Salter MW, Schachar R, D’Abate L, Bradley CA, Scherer SW, Copping NA, Pektova SP, Silverman J, Singh K, Kim N-S, Yoon K-J, Ming G-L, Song H, Spring S, Nakatani J, Nakai N, Nomura J, Takumi T, Tsai P, Bruce M, Jones K, Van de Water J, van Eede MC, Kerr TM, Muller C, VanderWeele JV, Vandewouw M, Weksberg R, Wevrick R, Belinson H, Wynshaw-Boris A, Zarbalis K, Trost B, Taylor M, Mars RB, Chakravarty MM, Kushki A, Anagnostou E, Lerch JP. 2025 Mar 12; bioRxiv,PreprintAssigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders
DOI:10.1101/2025.03.04.641443 -
Childs CJ, Poling HM, Chen K, Tsai Y-H, Wu A, Vallie A, Eiken MK, Huang S, Sweet CW, Schreiner R, Xiao Z, Spencer RC, Paris SA, Conchola AS, Villanueva JW, Anderman MF, Holloway EM, Singh A, Giger RJ, Mahe MM, Loebel C, Helmrath MA, Walton KD, Rafii S, Spence JR. Cell Stem Cell, 2025 Mar 21; S1934 - 5909.Journal ArticleCoordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature.
DOI:10.1016/j.stem.2025.02.007 -
Zhao X-F, Kohen R, Van Battum EY, Zeng Y, Zhang X, Johnson CN, Wang K, Lim BC, Oses-Prieto JA, Rasband JM, Burlingame AL, Pasterkamp RJ, Rasband MN, Giger RJ. 2024 Dec 19; bioRxiv,PreprintDiverse and Location-Specific Roles of PlexinA2, PlexinA4, and NCAM in Developing Hippocampal Mossy Fibers
DOI:10.1101/2024.12.15.628586 -
Nagy GN, Zhao XF, Karlsson R, Wang K, Duman R, Harlos K, El Omari K, Wagner A, Clausen H, Miller RL, Giger RJ, Jones EY. Nature Communications, 2024 Dec 1; 15 (1):Journal ArticleStructure and function of Semaphorin-5A glycosaminoglycan interactions
DOI:10.1038/s41467-024-46725-7 PMID: 38548715 -
Hoard TM, Liu K, Cadigan KM, Giger RJ, Allen BL. 2024 May 29;PreprintSemaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation.
DOI:10.1101/2024.05.29.596372 PMID: 38854152 -
Schmitd LB, Hafner H, Ward A, Asghari Adib E, Biscola NP, Kohen R, Patel M, Williamson RE, Desai E, Bennett J, Saxman G, Athaiya M, Wilborn D, Shumpert J, Zhao X-F, Kawaguchi R, Geschwind DH, Hoke A, Shrager P, Collins CA, Havton LA, Kalinski AL, Giger RJ. 2024 Apr 17;PreprintSarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.
DOI:10.1101/2024.03.04.583374 PMID: 38496662 -
Passino R, Finneran MC, Hafner H, Feng Q, Huffman LD, Zhao XF, Johnson CN, Kawaguchi R, Oses-Prieto JA, Burlingame AL, Geschwind DH, Benowitz LI, Giger RJ. Cell Reports, 2024 Mar 26; 43 (3):Journal ArticleNeutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration
DOI:10.1016/j.celrep.2024.113931 PMID: 38492223 -
Vitale S, Giger R, Schmitd LB, Haffner H. Journal of Biological Chemistry, 2024 Mar 27; 300 (3): 106740Journal ArticleAbstract 1390 Repair Schwann Cell Reprogramming After Peripheral Nerve Injury
DOI:10.1016/j.jbc.2024.106740
Department News
Roman Giger, Ph.D., is named as a 2024 American Association for the Advancement of Science (AAAS).
Department News
"Structure and function of Semaphorin-5A glycosaminoglycan interactions," has been published in Nature Communications.