Andrzej Dlugosz, MD
Poth Professor of Cutaneous Oncology
Associate Chair, Department of Dermatology
Professor of Dermatology and Professor of Cell and Developmental Biology
Medical School
[email protected]

Available to mentor
Andrzej Dlugosz, MD
Professor
  • About
  • Qualifications
  • Center Memberships
  • Recent Publications
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    About

    Work in my lab is focused on basal cell carcinoma, other Hedgehog-driven cancers, and a virus-associated cancer called Merkel cell carcinoma. We have developed and characterized multiple genetically-engineered mouse models to address fundamental questions in cancer biology, including identifying potential cells of origin of cancer, functions of oncogenic signaling in tumor maintenance, significance of cross-talk between signaling pathways in cancer, interactions between tumor cells and their microenvironment, and the regulation of tumor cell fate.

    Qualifications
    • MD
      Pennsylvania State University College of Medicine
    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Rogel Cancer Center
    Recent Publications See All Publications
    • Journal Article
      Identification of Meibomian gland stem cell populations and mechanisms of aging
      Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Wong SY, Iomini C, Millar SE. Nature Communications, 2025 Dec 1; 16 (1): DOI:10.1038/s41467-025-56907-6
      PMID: 39955307
    • Preprint
      Immunocompetent murine models recapitulate the heterogeneous tumor immune microenvironment of human liposarcoma
      Shafer AM, Kenna E, Golden L-AF, Elhossiny AM, Perry KD, Wilkowski J, Yan W, Kaczkofsky B, McGue J, Bresler SC, Courtney AH, Dalman JM, Galban CJ, Jiang W, Espinoza CE, Chugh R, Iyer MK, Frankel TL, di Magliano MP, Dlugosz AA, Angeles CV. 2025 Feb 6; bioRxiv, DOI:10.1101/2025.01.31.634916
    • Proceeding / Abstract / Poster
      1363 Evaluation of a novel Merkel cell carcinoma mouse model and response to anti-PD-1 immunotherapy
      Prieto K, Tordesillas L, de Mingo Pulido A, Sell B, Chavez-Chiang O, Aksit I, Harms P, Verhaegen M, Dlugosz A, Patel T, Coarfa C, Tsai K. 2024 Nov 8; a1526 - a1527. DOI:10.1136/jitc-2024-sitc2024.1363
    • Journal Article
      Development of a Multiplex Immunofluorescence Assay for Tumor Microenvironment Studies of Human and Murine Merkel Cell Carcinoma
      Sun L, Verhaegen ME, McGue J, Olivei AC, Dlugosz AA, Frankel TL, Harms PW. Laboratory Investigation, 2024 Oct 1; 104 (10): DOI:10.1016/j.labinv.2024.102128
      PMID: 39182611
    • Journal Article
      Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330, (S1476558618305323), (10.1016/j.neo.2019.01.003)]
      Choi JE, Verhaegen ME, Yazdani S, Malik R, Harms PW, Mangelberger D, Tien J, Cao X, Wang Y, Cieślik M, Gurkan J, Yazdani M, Jing X, Juckette K, Su F, Wang R, Zhou B, Apel IJ, Wang S, Dlugosz AA, Chinnaiyan AM. Neoplasia (United States), 2024 Sep 1; 55: DOI:10.1016/j.neo.2024.101019
      PMID: 38943995
    • Journal Article
      Identification of Meibomian gland stem cell populations and mechanisms of aging.
      Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Iomini C, Millar SE. bioRxiv, 2024 Aug 10; DOI:10.1101/2024.08.09.607015
      PMID: PMC11326261
    • Journal Article
      838 Immunotherapy-responsive preclinical model of Merkel cell carcinoma in immune-competent mice
      Verhaegen M, Singer K, Wilbert D, Moore A, Baumbick M, Walter E, Harms PW, Dlugosz A. Journal of Investigative Dermatology, 2024 Jul 20; 144 (8): s146 DOI:10.1016/j.jid.2024.06.854
    • Journal Article
      A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants
      Meyer-Schuman R, Cale AR, Pierluissi JA, Jonatzke KE, Park YN, Lenk GM, Oprescu SN, Grachtchouk MA, Dlugosz AA, Beg AA, Meisler MH, Antonellis A. Human Genetics and Genomics Advances, 2024 Jul 18; 5 (3): DOI:10.1016/j.xhgg.2024.100324
      PMID: 38956874