Laura Heyns Mariani, MD, MSCE
Associate Professor of Internal Medicine
Assistant Clerkship Director and Associate Fellowship Director - Nephrology
Medical School
[email protected]

Available to mentor

Laura Heyns Mariani, MD, MSCE
Associate Professor
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    Center Memberships
    • Center Member
      Precision Health Initiative
    Recent Publications See All Publications
    • Journal Article
      Proteinuria as an End Point in Clinical Trials of Focal Segmental Glomerulosclerosis
      Mariani LH, Trachtman H, Thompson A, Gillespie BS, Denburg M, Diva U, Geetha D, Greasley PJ, Hladunewich MA, Huizinga RB, Inrig JK, Komers R, Laurin LP, Little DJ, Nachman PH, Smith KA, Walsh L, Gibson KL. American Journal of Kidney Diseases, 2025 May 1; 85 (5): 610 - 617. DOI:10.1053/j.ajkd.2024.08.011
      PMID: 39455047
    • Preprint
      Computational characterization of lymphocyte topology on whole slide images of glomerular diseases
      Li X, Shah M, Liu Q, Zhou J, Sotolongo G, Hodgin JB, Mariani L, Holzman L, Janowczyk AR, Zee J, Lafata KJ, Barisoni L. 2025 Apr 17; medRxiv, DOI:10.1101/2025.04.12.25325548
    • Journal Article
      Risk factors for disease progression for adults and children with membranous nephropathy in the Cure Glomerulonephropathy Network (CureGN)
      Laurin L-P, Helmuth M, Almaani S, Ayoub I, Chen DP, Villegas LA, Nast CC, Robinson BM, Derebail VK, Waldman M, Bomback AS, Ahn W, Appel G, Appelbaum P, Babayev R, Bomback A, Canetta P, Chan B, D'Agati VD, Dogra S, Fernandez H, Gharavi A, Hines W, Husain SA, Jain N, Kiryluk K, Lin F, Marasa M, Markowitz G, Rasouly HM, Mohan S, Mongera N, Nestor J, Nickolas T, Radhakrishnan J, Rao M, Sanna-Cherchi S, Shirazian S, Stokes MB, Uy N, Valeri A, Vena N, Foroncewicz B, Moszczuk B, Mucha K, Perkowska-Ptasińska A, Ghiggeri GM, Lugani F, Ambruzs J, Liapis H, Baracco R, Jain A, Ashoor I, Aviles D, Srivastava T, Ahn S-Y, Devarajan P, Erkan E, Claes D, Stone H, Mason S, Gbadegesin R, Gomez-Mendez L, Greenbaum L, Wang C-S, Yin HJ, Cai Y, Jens G, Steinke J, Weaver D, Lane J, Cramer C, Pan C, Paloian N, Sreedharan R, Selewski D, Twombley K, Bowers C, Dreher M, Kallash M, Mahan J, Sharpe S, Smoyer W, Al-Uzri A, Iragorri S, Khalid M, Belsha C, Alge J, Braun M, Gomez AC, Wenderfer S, Vasylyeva T, Feig D, Fuentes GC, Hannah M, Nester C, Chishti A, Klein J, Katsoufis C, Seeherunvong W, Rheault M, Wong C, Mathews N, Barcia J, Swiatecka-Urban A, Bartosh S, Hunley T, Dharnidharka V, Gaut J, Laurinc L-P, Royal V, Achanti A, Budisavljevicc M, Self S, Ghossein C, Peleg Y, Wadhwanic S, Almaani S, Ayoub I, Nadasdy T, Parikh S, Rovinc B, Chang A, Fatima H, Julian B, Novak J, Renfrow M, Rizkc D, Chen D, Derebail V, Falka R, Gibson K, Glenn D, Hogan S, Jain K, Jennette JC, Mottlc A, Poultonb C, Saha MK, Fogo A, Sanghanic N, Kidd J, Muthusamy S, Schelling J, Houa J, Lemley K, Mika W, Russo P, Denburg M, Kogon A, Meyers K, Pradhan M, Matar RB, O'Toole J, Sedor J, Sethna C, Vento S, Atta M, Bagnasco S, Neu A, Sperati J, Adler S, Dai T, Dukkipati R, Fervenza F, Sethi S, Kaskel F, Brathwaite K, Reidy K, Weisstuch J, Wu M, Zhdanova O, Heymann J, Kopp J, Waldman M, Winkler C, Tuttle K, Krissberg J, Lafayette R, Fahmeedah K, Talley E, Hladunewich M, Parekh R, Avila-Casado C, Cattran D, Heather R, Boll P, Drexler Y, Fornoni A, Blazius B, Hodgin J, Oliverio A, Hogan J, Holzman L, Palmer M, Coppock G, Abromovitz B, Mortiz M, Alpers C, Jefferson JA, Brown E, Sambandam K, Roehm B, Graff. a J, Nast C, Barisoni L, Smith A, Gillespie B, Robinson B, Kretzler M, Mariani L, Guay-Woodford LM. Kidney International Reports, 2025 Mar 27; DOI:10.1016/j.ekir.2025.03.027
    • Preprint
      Framework for precision medicine in focal segmental glomerulosclerosis: Translation of sparsentan-responsive genes in a rat model to kidney disease associated proteins in biofluids.
      Eddy S, Nair V, Hartman J, Fermin D, Eichinger F, Godfrey B, Ju W, Hodgin JB, Mariani LH, Bedard PW, Jenkinson CP, Hendry B, Komers R, Inrig J, Kretzler M, Nephrotic Syndrome Study Network (NEPTUNE) . 2025 Feb 27; DOI:10.1101/2025.02.26.25322958
      PMID: 40061330
    • Preprint
      Asengeprast, a Novel G-Protein Coupled Receptor 68 Antagonist, Reverses Clinically Relevant Inflammatory and Fibrotic Pathways in Chronic Kidney Disease
      Eddy S, Papadimitriou MP, Edgley AJ, Langham RG, Khong FL, Kong RCK, Carbone SE, Kompa AR, Zhang Y, Cox A, Mitchell L, Subramanian L, Martini S, Hartman J, Eichinger F, Godfrey B, Mariani LH, Kretzler M, Kelly DJ, Network NSS. 2025 Feb 26; medRxiv, DOI:10.1101/2025.02.21.25322641
    • Journal Article
      Clinical Relevance of Computational Pathology Analysis of Interplay between Kidney Microvasculature and Interstitial Microenvironment
      Chen Y, Wang B, Demeke D, Fan F, Berthier C, Mariani L, Lafata K, Holzman L, Hodgin J, Janowczyk A, Barisoni L, Madabhushi A. Clinical Journal of the American Society of Nephrology, 2025 Feb 1; 20 (2): 239 - 255. DOI:10.2215/CJN.0000000597
      PMID: 39714939
    • Journal Article
      WCN25-3719 URINARY TNFR2 IS ASSOCIATED WITH KIDNEY DAMAGE IN PATIENTS WITH NEPHROTIC SYNDROME
      Nair V, Lee E, Eddy S, Chinnakotla S, Chaki S, Helmuth M, Fermin D, Hodgin J, Mariani L, Kretzler M, Ju W. Kidney International Reports, 2025 Jan 28; 10 (2): s580 DOI:10.1016/j.ekir.2024.11.1035
    • Journal Article
      Proteinuria Trajectory and Disease Progression in Children and Adults with IgA Nephropathy/Vasculitis
      Glenn DA, Carver AW, Helmuth ME, Smith AR, Lafayette RA, Ravipati P, Oliverio AL, Rizk DV, Novak J, Lugani F, Bartosh SM, Mucha K, Kiryluk K, Saha MK, Nast CC, Hou J, Biederman LE, Messias N, Rosenberg AZ, Reich HN, Canetta PA, Nachman PH, Nester C, Bou-Matar R, Wadhwani S, Mariani LH, Khalid M. Clinical Journal of the American Society of Nephrology, 2025 Jan 1; DOI:10.2215/CJN.0000000707