Arul Chinnaiyan, M.D., Ph.D., the S.P. Hicks Professor of Pathology and Urology, was awarded the 2022 Sjöberg Prize by the Royal Swedish Academy of Sciences, which also awards Nobel Prizes.
Chinnaiyan is being honored for the discovery of recurrent gene fusions in prostate cancer, a groundbreaking finding initially published in 2005 that has led to a better understanding of how prostate cancer develops and improved methods to detect the disease.
"It is a great honor to be selected for this award and to follow in the footsteps of the luminaries who have received this award in the past," says Chinnaiyan, who is director of the Michigan Center for Translational Pathology and a member of the University of Michigan Health Rogel Cancer Center.
This is the sixth time the Sjöberg Prize has been awarded. It was established by businessman Bengt Sjöberg, who was diagnosed with cancer and donated two billion Swedish kronor to promote scientific research primarily focused on cancer, health, and the environment. The Royal Swedish Academy selects the laureates, and the Sjöberg Foundation provides the financing. Winners receive $1 million, which includes $100,000 personal prize and $900,000 to support their research.
Chinnaiyan's lab found that a prostate-specific gene called TMPRSS2 fuses with the gene ERG, to drive prostate cancer development. This gene fusion, fueled by the hormone androgen, acts as an "on switch" to trigger prostate cancer. The fusion is an exquisitely specific biomarker of prostate cancer that can be detected in prostate needle biopsies and non-invasively in the urine of men with prostate cancer, which has led to improved methods for screening and diagnosing prostate cancer. It also represents a potential target for treatment, and research is ongoing to develop drugs against this genetic anomaly.
"The Sjöberg Prize is an incredibly well-deserved recognition for Dr. Chinnaiyan," says Eric Fearon, M.D., Ph.D., director of the Rogel Cancer Center. "His discoveries are making a real difference for people with cancer."